Peptune GHK-Cu
The copper complex of the tripeptide glycyl-histidyl-lysine, one of the most cited small peptides in research.
$45.00
In stock
- Class
- Copper tripeptide
- Amount per vial
- 50 mg
- Form
- Lyophilized powder
- Length
- 3 residues
- CAS number
- 89030-95-5 (copper complex); 49557-75-7 (GHK)
- Molecular weight
- 401.9 g/mol
- Appearance
- Blue to blue-green powder
For laboratory research use only · Certificate of analysis · Full specifications
Documentation
Certificate of analysis
No certificate is published for this product yet. Contact us to check the documentation for the current batch before you order; published certificates are listed in the documentation library.
Overview
About this product
GHK is the tripeptide glycyl-L-histidyl-L-lysine. It binds copper(II) with high affinity, and the resulting complex, GHK-Cu, is the form most often studied. It has been examined in cell and tissue models of extracellular-matrix signalling, gene-expression profiling and copper transport, and in analytical work on peptide–metal coordination. Studies comparing GHK with GHK-Cu should document how each material was prepared, since free copper, free peptide and the complex can behave differently in the same assay. Supplied as a blue lyophilized powder in a sealed vial. What the research shows The studies cited here are in cells and animals. A 1988 study in fibroblast cultures reported increased collagen synthesis with GHK-Cu from picomolar concentrations, with the largest effect at a nanomolar concentration and no change in cell number. In a 2015 study, 72 rats after anterior cruciate ligament reconstruction were randomised to saline or one of two GHK-Cu concentrations; knee laxity differed from saline at 6 weeks but not at 12 weeks, and ultimate load and histology scores did not differ. A 2022 study in mice exposed to cigarette smoke for 12 weeks reported fewer emphysematous changes and lower IL-1 beta and TNF-alpha in lung lavage with GHK-Cu. Sources: Maquart et al., FEBS Letters, 1988, PMID 3169264. Fu et al., Journal of Orthopaedic Research, 2015, PMID 25731775. Zhang et al., Frontiers in Molecular Biosciences, 2022, PMID 35936787. For laboratory research use only. Not for human or veterinary use. Purity and identity are stated on the batch certificate, published on this page once it is on file.
Research profile
GHK-Cu in the literature
Research areas · 0–5
The molecule
About this compound
GHK-Cu is the copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The sequence is Gly-His-Lys. The copper ion is part of the complex, which is why the name carries Cu. The vial contains 50 mg of that complex, as a lyophilized powder. The same identity is how the material is specified in laboratory catalogues: sequence, copper complex, amount, and sealed vial. Peptune does not print a purity percentage on this page.
- Class
- Copper tripeptide
- Also known as
- Copper tripeptide-1, glycyl-L-histidyl-L-lysine copper complex
- CAS number
- 89030-95-5 (copper complex); 49557-75-7 (GHK)
- Sequence
- Glycyl-L-histidyl-L-lysine (Gly-His-Lys)
- Length
- 3 residues
- Molecular formula
- C14H22CuN6O4
- Molecular weight
- 401.9 g/mol
- Target in the literature
- Copper(II)-binding tripeptide
- Form
- Lyophilized powder
- Amount per vial
- 50 mg
- Appearance
- Blue to blue-green powder
- Solubility
- Sterile water or bacteriostatic water
- Storage (unopened)
- −20 °C long term, 2 to 8 °C short term; sealed and away from light
- Storage (in solution)
- 2 to 8 °C, away from light; do not freeze
- Packaging
- Sealed vial
- Notes
- Complex: Copper-binding tripeptide
Published research
These are published papers about the molecule. A paper is not a dose, not medical advice, and not evidence that this vial is for human or veterinary use.
- GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
BioMed Research International · 2015 · PMID 26236730
A review of published cell and tissue experiments on the tripeptide. The review's conclusions are not a claim about this vial.
- The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6.
Redox Biology · 2024 · PMID 38879894
A mouse silicosis model of the copper complex. Listed as the experiment that was run, not as a result for this vial.
For laboratory research use only. Not for human or veterinary use. The amount on the label is the contents of the vial, not a dose.
Ordering in Canada
Buying Peptune GHK-Cu in Canada
- Can I buy Peptune GHK-Cu in Canada?
- Yes. Peptune sells Peptune GHK-Cu online for laboratory research use only, with tracked delivery to every province and territory in Canada.
- How much is Peptune GHK-Cu?
- 50 mg: $45, in Canadian dollars. Free shipping on orders of $150 or more.
- Is there a certificate of analysis for Peptune GHK-Cu?
- The certificate of analysis for the current batch of Peptune GHK-Cu is published on this page and in the COA library as soon as it is on file.
- How is Peptune GHK-Cu supplied?
- As a lyophilized powder in a sealed vial, labelled with the compound and the amount: 50 mg. The amount is the contents of the vial, not a dose. Keep it sealed, dry, cold and away from light.
- How do I pay?
- By Interac e-Transfer or crypto. The payment instructions arrive by email after you place the order, and nothing is charged before that step.
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