Peptune MOTS-c
A sixteen-residue peptide encoded in mitochondrial DNA, studied in metabolic and mitochondrial research.
$59.00
In stock
- Class
- Mitochondrial peptide
- Amount per vial
- 10 mg
- Form
- Lyophilized powder
- Length
- 16 residues
- CAS number
- 1627580-64-6
- Molecular weight
- 2,174.6 g/mol
- Appearance
- White powder
For laboratory research use only · Certificate of analysis · Full specifications
Documentation
Certificate of analysis
No certificate is published for this product yet. Contact us to check the documentation for the current batch before you order; published certificates are listed in the documentation library.
Overview
About this product
MOTS-c is a sixteen-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, one of a small family of mitochondrial-derived peptides. Since its description in 2015 it has been studied in cell and animal models of energy metabolism, AMPK signalling and the communication between mitochondria and the nucleus. Research with MOTS-c benefits from careful controls for cell type and metabolic state, since baseline mitochondrial activity varies widely between models. Supplied as a lyophilized powder in a sealed vial. What the research shows In the papers cited here, MOTS-c was given only in laboratory and mouse experiments; the human work measured the body's own MOTS-c. A 2018 study reported that MOTS-c moves into the nucleus under metabolic stress, in an AMPK-dependent manner, and regulates nuclear gene expression. A 2021 study reported greater physical performance in young, middle-aged and old mice given MOTS-c, and found that exercise raised endogenous MOTS-c in human skeletal muscle and circulation. A 2018 study of 10 lean and 10 obese adults found similar plasma MOTS-c in both groups, 0.48 and 0.52 ng/mL. Sources: Kim et al., Cell Metabolism, 2018, PMID 29983246. Reynolds et al., Nature Communications, 2021, PMID 33473109. Cataldo et al., Journal of Investigative Medicine, 2018, PMID 29593067. For laboratory research use only. Not for human or veterinary use. Purity and identity are stated on the batch certificate, published on this page once it is on file.
Research profile
MOTS-c in the literature
Research areas · 0–5
The molecule
About this compound
MOTS-c is a peptide of 16 amino acids encoded in mitochondrial DNA, in the 12S rRNA region, rather than in the cell nucleus. The sequence reported with the original description is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg. The vial contains 10 mg.
- Class
- Mitochondrial peptide
- Also known as
- Mitochondrial open reading frame of the 12S rRNA type-c
- CAS number
- 1627580-64-6
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Length
- 16 residues
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2,174.6 g/mol
- Target in the literature
- Mitochondrial-derived peptide studied in AMPK signalling
- Form
- Lyophilized powder
- Amount per vial
- 10 mg
- Appearance
- White powder
- Solubility
- Sterile water or bacteriostatic water
- Storage (unopened)
- −20 °C long term, 2 to 8 °C short term; sealed and away from light
- Storage (in solution)
- 2 to 8 °C, away from light; do not freeze
- Packaging
- Sealed vial
- Notes
- Encoded in: Mitochondrial 12S rRNA, not the nuclear genome
Published research
These are published papers about the molecule. A paper is not a dose, not medical advice, and not evidence that this vial is for human or veterinary use.
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Cell Metabolism · 2015 · PMID 25738459
The paper that first described MOTS-c, including mouse experiments. The title is the paper's claim, not a claim about this vial.
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.
Frontiers in Endocrinology · 2023 · PMID 36761202
A review of the 16-residue peptide. Peptune does not adopt the review's therapeutic framing.
For laboratory research use only. Not for human or veterinary use. The amount on the label is the contents of the vial, not a dose.
Ordering in Canada
Buying Peptune MOTS-c in Canada
- Can I buy Peptune MOTS-c in Canada?
- Yes. Peptune sells Peptune MOTS-c online for laboratory research use only, with tracked delivery to every province and territory in Canada.
- How much is Peptune MOTS-c?
- 10 mg: $59, in Canadian dollars. Free shipping on orders of $150 or more.
- Is there a certificate of analysis for Peptune MOTS-c?
- The certificate of analysis for the current batch of Peptune MOTS-c is published on this page and in the COA library as soon as it is on file.
- How is Peptune MOTS-c supplied?
- As a lyophilized powder in a sealed vial, labelled with the compound and the amount: 10 mg. The amount is the contents of the vial, not a dose. Keep it sealed, dry, cold and away from light.
- How do I pay?
- By Interac e-Transfer or crypto. The payment instructions arrive by email after you place the order, and nothing is charged before that step.
Verified buyers
Reviews
No reviews yet. Reviews come from verified buyers only, and each one is checked before it appears.
Bought this? Write a review
Loading…
