Peptune Retatrutide
A single peptide that activates the GIP, GLP-1 and glucagon receptors, studied in metabolic-receptor research.
$90.00
In stock
- Class
- Peptide analogue
- Amount per vial
- 10 mg and 20 mg, sold separately
- Form
- Lyophilized powder
- Length
- 39 residues
- CAS number
- 2381089-83-2
- Molecular weight
- 4,731.3 g/mol
- Appearance
- White powder
For laboratory research use only · Certificate of analysis · Full specifications
Documentation
Certificate of analysis
No certificate is published for this product yet. Contact us to check the documentation for the current batch before you order; published certificates are listed in the documentation library.
Overview
About this product
Retatrutide (LY3437943) is a synthetic peptide designed to activate three receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). That makes it a reference compound for research into multi-receptor agonism, receptor bias and how the three pathways interact. Because three receptors can contribute to one observation, useful designs include single-receptor agonists or receptor-specific cell lines as comparators. Available in 10 mg and 20 mg vials, each supplied as a lyophilized powder in a sealed vial. What the research shows Retatrutide has been studied in randomised human trials. In the phase 3 TRIUMPH-1 trial, published in 2026, 2,339 adults with obesity and without diabetes were randomised to retatrutide or placebo for 80 weeks; mean body weight changed by -25.0% in the highest-dose group and by -3.9% with placebo, and the most common adverse events were gastrointestinal. In the 40-week phase 3 TRANSCEND-T2D-1 trial of 537 adults with type 2 diabetes, glycated haemoglobin changed by -1.69% to -1.94% across the three retatrutide groups and by -0.81% with placebo, and no severe hypoglycaemia was reported. Sources: Jastreboff et al., New England Journal of Medicine, 2026, PMID 42814954. Bajaj et al., The Lancet, 2026, PMID 42250575. For laboratory research use only. Not for human or veterinary use. Purity and identity are stated on the batch certificate, published on this page once it is on file.
Research profile
Retatrutide in the literature
Research areas · 0–5
The molecule
About this compound
Retatrutide is a synthetic peptide of 39 amino acids. In the published literature it is also identified as LY3437943, and it is described as engaging the GLP-1, GIP and glucagon receptors. That is the published description of the molecule. Peptune sells it as a 10 mg vial and a 20 mg vial. Those figures are the contents of each vial. They are not a dose.
- Class
- Peptide analogue
- CAS number
- 2381089-83-2
- Length
- 39 residues
- Molecular formula
- C221H342N46O68
- Molecular weight
- 4,731.3 g/mol
- Target in the literature
- GIP, GLP-1 and glucagon receptor agonist
- Half-life (published)
- About 6 days in people (phase 1b, PMID 36354040)
- Form
- Lyophilized powder
- Amount per vial
- 10 mg and 20 mg, sold separately
- Appearance
- White powder
- Solubility
- Sterile water or bacteriostatic water
- Storage (unopened)
- −20 °C long term, 2 to 8 °C short term; sealed and away from light
- Storage (in solution)
- 2 to 8 °C, away from light; do not freeze
- Packaging
- Sealed vial
- Notes
- Literature code: LY3437943
- Receptors named in the literature: GLP-1, GIP and glucagon
Published research
These are published papers about the molecule. A paper is not a dose, not medical advice, and not evidence that this vial is for human or veterinary use.
- Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial.
New England Journal of Medicine · 2023 · PMID 37366315
A phase 2 trial of LY3437943. The paper is not a dose and not evidence that this research vial is a medicine.
- Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial.
Nature Medicine · 2024 · PMID 38858523
A phase 2a trial. Listed so the record can be read. Not an instruction and not a claim about this vial.
For laboratory research use only. Not for human or veterinary use. The amount on the label is the contents of the vial, not a dose.
Ordering in Canada
Buying Peptune Retatrutide in Canada
- Can I buy Peptune Retatrutide in Canada?
- Yes. Peptune sells Peptune Retatrutide online for laboratory research use only, with tracked delivery to every province and territory in Canada.
- How much is Peptune Retatrutide?
- 10 mg: $90; 20 mg: $149, in Canadian dollars. Free shipping on orders of $150 or more.
- Is there a certificate of analysis for Peptune Retatrutide?
- The certificate of analysis for the current batch of Peptune Retatrutide is published on this page and in the COA library as soon as it is on file.
- How is Peptune Retatrutide supplied?
- As a lyophilized powder in a sealed vial, labelled with the compound and the amount: 10 mg and 20 mg, sold separately. The amount is the contents of the vial, not a dose. Keep it sealed, dry, cold and away from light.
- How do I pay?
- By Interac e-Transfer or crypto. The payment instructions arrive by email after you place the order, and nothing is charged before that step.
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